| Registro completo |
| Provedor de dados: |
BABT
|
| País: |
Brazil
|
| Título: |
Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility
|
| Autores: |
Graça,José Ronaldo Vasconcelos
Bezerra,Mirna Marques
Lima,Vilma
Rodrigues,José Ariévilo Gurgel
Monteiro,Diego Levi Silveira
Quinderé,Ana Luíza Gomes
Amorim,Rodrigo César das Neves
Paula,Regina Célia Monteiro de
Benevides,Norma Maria Barros
|
| Data: |
2011-10-01
|
| Ano: |
2011
|
| Palavras-chave: |
Halymenia floresia
Sulfated polysaccharides
Gut motility
|
| Resumo: |
The aim of this work was to study the effect of Halymenia floresia (Hf) on duodenum contractility, and on experimental protocols of gastric compliance (GC) in rats. Fraction Hf2s exhibited a concentration-dependent myocontractile effect (EC50 12.48 µg/ml), and an inhibitory effect after consecutive washing. The contractile response promoted by Hf2s in the duodenum strips was completely inhibited by verapamil, and the effects were prevented in the presence of Ca2+-free medium. The pretreatment with atropine prevented the Hf2s myocontractile effect. Hf2s was also capable to decrease the GC (from 3.8±0.06 to 3.4±0.13 ml, P<0.05), which did not return to basal levels after more 50 min of observation. These results indicated that the algal polysaccharide possessed in vitro and in vivo gastrointestinal effects.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500008
|
| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
|
| Relação: |
10.1590/S1516-89132011000500008
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Archives of Biology and Technology v.54 n.5 2011
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
